Computer Aided Applications in Pharmaceutical Technology

In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology.

Computer Aided Applications in Pharmaceutical Technology

Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

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Computer-Aided Applications in Pharmaceutical Technology
Language: en
Pages: 300
Authors: Jelena Djuris
Categories: Medical
Type: BOOK - Published: 2013-04-10 - Publisher: Elsevier

Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and
Computer-aided applications in pharmaceutical technology
Language: en
Pages: 300
Authors: Ljiljana Djekic, Dragana Vasiljevic, Marija Primorac
Categories: Technology & Engineering
Type: BOOK - Published: 2013-04-10 - Publisher: Elsevier Inc. Chapters

This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of
Computer-aided applications in pharmaceutical technology
Language: en
Pages: 300
Authors: Sandra Grbic, Jelena Parojcic, Zorica Djuric
Categories: Technology & Engineering
Type: BOOK - Published: 2013-04-10 - Publisher: Elsevier Inc. Chapters

This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well
Computer-aided applications in pharmaceutical technology
Language: en
Pages: 300
Authors: Jelena Djuris, Svetlana Ibric, Zorica Djuric
Categories: Technology & Engineering
Type: BOOK - Published: 2013-04-10 - Publisher: Elsevier Inc. Chapters

This first chapter introduces the concept of quality-by-design (QbD) and its role in pharmaceutical product development. QbD assures the quality of a pharmaceutical product through scientific development and risk management tools, and will eventually enable real-time release, regardless of the formulation type. Several guidelines on pharmaceutical development, quality risk management,
Computer-aided applications in pharmaceutical technology
Language: en
Pages: 300
Authors: Jelena Djuris, Svetlana Ibric, Zorica Djuric
Categories: Technology & Engineering
Type: BOOK - Published: 2013-04-10 - Publisher: Elsevier Inc. Chapters

This chapter provides a basic theoretical background on experimental design application and interpretation. Techniques described include screening designs, full and fractional factorial designs, Plackett–Burman design, D-optimal designs, response surface methodology, central composite designs, Box–Behnken design, and mixture designs, etc. The reader will be introduced to the experimental domains covered by