Secretion and Action of Gonadotropins

Since that time a new field was opened for the studies of gonadotropins. During this time, highly purified preparations of gonadotropins were available for research and clinical treatment.

Secretion and Action of Gonadotropins

In 1920, Hirose demonstrated the luteinising effect of placental tissue and one year later, Evans and Long described luteinised ovaries in rats treated with hypophysial extracts. In 1926, Zondek and Aschheim as well as Smith, independently of each other, showed that a gonad-stimulating hormone was secreted by the adenohypophysis. In 1927, Aschheim and Zondek found their "Prolan" in human pregnancy urine and the first reliable pregnancy test was available. In the following years it could be demonstrated that the gonadotropic hormones from pituitary and from pregnancy urin were not of identical structure. During the years 1931 - 1933 Fevold and coworkers prepared follicle stimulating hormone from sheep pituitaries which were free of other hormone activities. Already in 1934, Collip found "antihormones" in animals treated with proteinhormones from animals of another species. It could be shown that they were antibodies against these hormones and this was the future basis for the immunological era starting in 1960. The quantitative determination of gonadotropins has been performed over several decades by difficult bioassays and since 1960 immunological and later radioimmunological assays became available. Since that time a new field was opened for the studies of gonadotropins. During this time, highly purified preparations of gonadotropins were available for research and clinical treatment. I recall the first successful attempt of inducing follicle growth and ovulation by Gemzell and coworkers 1958 as well as by Lunenfeld and Bettendorf at about the same time.

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Secretion and Action of Gonadotropins
Language: en
Pages: 96
Authors: B. Runnebaum, T. Rabe, L. Kiesel, W. E. Merz
Categories: Medical
Type: BOOK - Published: 1984 - Publisher: Springer

In 1920, Hirose demonstrated the luteinising effect of placental tissue and one year later, Evans and Long described luteinised ovaries in rats treated with hypophysial extracts. In 1926, Zondek and Aschheim as well as Smith, independently of each other, showed that a gonad-stimulating hormone was secreted by the adenohypophysis. In
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Language: en
Pages: 420
Authors: Mary Hunzicker-Dunn, Neena B. Schwartz
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

The chapters in this book represent presentations at the first meeting ever held on the regulation and actions of follicle stimulating hormone. The meeting took place on the campus of Northwestern University, Evanston, Illinois, from October 25 to 28, 1990. The idea for this meeting was conceived by Neena B.
Effects of Estradiol on Gonadotropin Secretion and Gonadotrope Function During Nutrient Restriction in Orchidectomized Sheep
Language: en
Pages: 278
Authors: Jonathon Lee Beckett
Categories: Medical
Type: BOOK - Published: 1996 - Publisher:

Books about Effects of Estradiol on Gonadotropin Secretion and Gonadotrope Function During Nutrient Restriction in Orchidectomized Sheep
The Effects of Phytoestrogens on Basal and GnRH-induced Gonadotropin Secretion from Ovine Pituitary Cells in Culture
Language: en
Pages:
Authors: Sergio Adrian Arispe
Categories: Medical
Type: BOOK - Published: 2012 - Publisher:

Phytoestrogens (PE) are non-steroidal compounds in livestock diets that disrupt female cyclicity and contribute to infertility. Acting as exogenous estrogens, PEs disrupt the normal episodic release of GnRH from hypothalamic loci to suppress fertility. While the affects at hypothalamic loci are well documented, their affects on the pituitary remains unclear.
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Language: en
Pages: 344
Authors: I.S. Parhar
Categories: Science
Type: BOOK - Published: 2002-11-22 - Publisher: Elsevier

This volume summarizes the evolution and physiology of GnRH molecules and receptors, and provides insight as to how social behavior influences cellular and molecular events in the brain from a comparative perspective. The chapters in this volume are divided into three major sections: Development and Cell Migration, GnRH Receptors, Physiology